ABSTRACT
OBJECTIVE@#To investigate the histogenesis, morphological features and biologic behaviors of granular cell tumor(GCT) of the larynx.@*METHOD@#A retrospective study was performed in three cases of GCT in our hospital, the clinical data were studied with histopathologic analysis, histochemical and immunohistochemical staining, and combining with the analysis of domestic and foreign literatures.@*RESULT@#Histopathologic features of laryngeal GCT were identical to that in soft tissues, but pseudoepitheliomatous hyperplasia was present in 50%-60% cases of the tumor. This disease may originate from the neurogenic Schwann cell, S-100 could be positive in immunohistochemistry.@*CONCLUSION@#Laryngeal GCT is a rare benign tumor and can be cured by local excision.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Diagnosis, Differential , Granular Cell Tumor , Diagnosis , Laryngeal Neoplasms , Diagnosis , Retrospective StudiesABSTRACT
OBJECTIVE@#To investigate the clinical, pathological character and differential diagnosis of laryngeal verrucous carcinoma.@*METHOD@#Clinical data of one case with laryngeal verrucous carcinoma in our hospital were retrospectively analyzed.@*RESULT@#The diagnosis of verrucous carcinoma was difficult and depend on repeated biopsy. Verrucous carcinoma of larynx is a highly differentiated variant of squamous carcinoma that has peculiar clinical and morphological features. The basement membrane is not invaded. It is prone to distant metastasis, than to local recurrence. The case underwent the partial laryngectomy, and was followed up for more than 4 years with no recurrence.@*CONCLUSION@#Verrucous carcinoma of the larynx is a special pattern of the well-differentiated squamous cancer. A correct diagnosis requires close cooperation between the laryngologist and the pathologist. The main treatment of verrucous carcinoma is complete surgical excision to reserve larynx function as far as possible and improve the quality of life.
Subject(s)
Humans , Male , Middle Aged , Carcinoma, Verrucous , Diagnosis , General Surgery , Laryngeal Neoplasms , Diagnosis , General Surgery , Retrospective StudiesABSTRACT
OBJECTIVE@#To analyze the clinical presentation, pathological feature, therapy and outcome of epithelioid hemangioma.@*METHOD@#We reviewed the clinical findings, pathologic changes and outcomes of six cases with epithelioid hemangioma from Aug. 2007 to Sept. 2011.@*RESULT@#There are four males and two females ranged from 18 to 44 years(median year was 29.5). Primary lesions sites included the parotid gland, neck and ear. Four lesions presented as a solitary mass, and no patient had history of trauma. All patients were treated by surgeries, and not complemented by medical. There were four patients relapsed during follow-up, and three of them accepted reoperations (two patients received postoperative radiotherapies), and no recurrence was detected.@*CONCLUSION@#Epithelioid hemangioma represents a benign vascular tumor, accurate diagnosis relies on clinical characteristic, histopathologic appearance and immunohistochemical findings, and it must be differentiated with Kimura's disease. The main treatment is surgery and the prognosis is well, but easy to recurrence.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Diagnosis, Differential , Head and Neck Neoplasms , Diagnosis , Hemangioma , Diagnosis , PrognosisABSTRACT
ObjectiveTo study prognostic factors and surgical extent of papillary thyroid microcarcinona (PTMC). MethodsLiteratures about PTMC were searched. Relationship between prognostic factors and recurrence after initial operation was analyzed by meta analysis. The surgical extent of PTMC was discussed. Results A total of 12 retrospective studies were included. Meta analysis results showed that factors such as male, tumor size ＞ 5 mm, nonincidental, positive lymphnode, multifocus, and capsular invasion were related to recurrence after initial surgery. Age above 45 years had nothing to do with the recurrence rate of PTMC. There was no signifi.cant difference in recurrence rate between prophylactic neck dissection groups and the groups without prophylactic neck dissection. ConclusionsMany factors are related to the prognosis of PTMC. The surgical extent depends on prognostic factors. Prophylactic neck dissection is not supposed to be conventional surgical procedure for PTMC. Bilateral central lymph node dissection is appropriate to PTMC with positive lymph node.